UN METODO SPETTROSCOPICO PER LA QUANTIFICAZIONE DI FARMACI IN FLUIDI BIOLOGICI

Autori

  • Paolo Maria Ossi, et al. (#) Politecnico di Milano, Dipartimento di Energia, Milano | (#) La nota è il risultato di un lavoro di ricerca condotto in collaborazione con: Chiara Zanchi, Matteo Pistaffa, Andrea Lucotti, Matteo Tommasini, Sebastiano Trusso, Ugo De Grazia, Emilio Ciusani, Marina Casazza, Silvana Franceschetti

DOI:

https://doi.org/10.4081/scie.2017.592

Abstract

An innovative spectroscopic technique to determine the drug concentration in biological fluids is discussed. We introduce the context of drugs with narrow therapeutic index in relation to epilepsy and Parkinson’s disease. We then recapitulate the essentials of Raman and enhanced Raman spectroscopy that makes use of a corrugated metallic surface. Optimizing the intensification of the spectroscopic signatures of a given analyte critically depends on the metal choice and on the fine details of the induced surface nanostructuring. We review the topic with emphasis on noble metal surfaces synthesized by pulsed laser ablation in inert gas at high pressure. The performance of optimized surfaces to determine the drug concentration in different fluids, including human blood, is discussed with reference to carbamazepine, an anti-epileptic drug widely adopted in Developing Countries and to apomorphine, a drug used to treat via subcutaneous injection patients with important manifestations of Parkinson’s disease. 

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Pubblicato

2020-03-26

Come citare

Ossi, et al. (#), P. M. (2020). UN METODO SPETTROSCOPICO PER LA QUANTIFICAZIONE DI FARMACI IN FLUIDI BIOLOGICI. Istituto Lombardo - Accademia Di Scienze E Lettere - Rendiconti Di Scienze. https://doi.org/10.4081/scie.2017.592