Articoli
Volume 155 • (2021) Rendiconti - Classe di Scienze Matematiche e Naturali
https://doi.org/10.4081/scienze.2021.776
VIDĒRE EST CREDERE: LA STRUTTURA AD ALTA RISOLUZIONE DEL CANALE DEL PACEMAKER HCN4
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Ricevuto: 31 gennaio 2022
Pubblicato: 31 gennaio 2022
Pubblicato: 31 gennaio 2022
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HCN channels (HCN1-4) generate the If current that controls automaticity and rhythm of the heartbeat. Using single-particle electron cryo-microscopy (cryo-EM), we obtained the structure of HCN4, bound and unbound to the cAMP ligand and with the pore in open and closed configuration. Analysis of the structures reveals a coordination site for the Mg2+ ion which, by linking two domains of the protein, facilitates channel gating by cyclic nucleotides. The open pore configuration used in molecular dynamics simulations provided information on the mechanisms of permeation of K+/Na+ ions and on the mechanism of action of ivabradine, a drug used in the treatment of angina.
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Come citare
VIDĒRE EST CREDERE: LA STRUTTURA AD ALTA RISOLUZIONE DEL CANALE DEL PACEMAKER HCN4. (2022). Istituto Lombardo - Accademia di Scienze e Lettere - Rendiconti di Scienze. https://doi.org/10.4081/scienze.2021.776