The personal viewpoint of a theoretical physicist about the relation between reality and physical science is exposed, starting from his personal experience in the context of quantum foundations and quantum information theory. The effectiveness of an axiomatic approach is argued as a navigation system between the abstract landscape of quantum theory and the reality of facts, along a road that is intrinsically unaccessible to classical conceptual maps. The present approach requires physics to accept the notion of information at its deepest level, in place of matter and space-time, that are recovered only as an effective description of phenomena on a secondary level. As a result of the above operation, a simplified conceptual scenario is achieved, where new possibilities are available for facing the open challenges of theoretical physics.
